I have often cried out loud in sheer misery at the hopelessness of life, my life.
Her eyes, always sad, now looked with particular hopelessness at her reflection in the glass.
His attitude is one not of bitterness but of calm hopelessness, with an occasional tinge of disgust or contempt.
Clinical depression is a serious illness characterized by feelings of intense sadness, hopelessness and despair.
When he was informed that among others awaiting him in his reception room there was a Frenchman who had brought a letter from his wife, the Countess Helene, he felt suddenly overcome by that sense of confusion and hopelessness to which he was apt to succumb.
